![]() Patients with persistent MRD pre-transplant had survival rates of 41% leukemia-free and 64% overall. The MRD-negative patients had a leukemia-free survival rate of 83% and overall survival rate of 92% – much higher when compared with patients with persistent MRD. The life expectancy increased markedly in those who tested negative for bone marrow MRD before their allogeneic transplant. Testing positive for small amounts of cancer cells after treatment (minimal residual disease or MRD) in children with acute lymphoblastic leukemia was a risk factor for relapse. Prevention of viral infections and management of graft-versus-host disease (or GVHD, in which immune cells in donor tissue attack the transplant patient’s own tissues), and reimmunization through vaccination are important for optimal survival. What is the risk of complications or side effects from bone marrow transplantation? Transplants of younger patients have a higher chance of success.Īdditionally, when both the donor and recipient are cytomegalovirus ( CMV) negative, survival rates are higher. Patients in remission or with stabilized disease generally have a much better result than those with the disease in later stages or relapse. Transplanting the patient’s own bone marrow from an unaffected bone to a diseased one (autologous bone marrow transplant) along with chemotherapy has improved survival rates with certain cancers such as:Īutologous transplants have not enhanced the survival rates with other pediatric malignant cancers, with metastatic alveolar rhabdomyosarcoma, or with metastatic Ewing sarcoma. ![]() The survival rates after transplant for patients with acute leukemia in remission are 55% to 68% with related donors and 26% to 50% if the donor is unrelated. Understandably, transplants for patients with nonmalignant diseases have a much better success rate with 70% to 90 % survival with a matched sibling donor and 36% to 65% with unrelated donors. How long can you live after a bone marrow transplant? ![]()
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